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Google has advocated the use of CRISPR to prevent heart disease

Have you ever wondered why some lucky people eat chips, do not play sports and, nevertheless, do not clog arteries? Perhaps this is due to the fact that they have happy genes. And here, Alphabet (the parent company of Google) is funding a start-up company that plans to use gene editing to distribute successful DNA variants using the CRISPR tool. You should already know what CRISPR is. Cardiologists involved in this movement say that DNA injection injections can "provide lifelong protection against heart disease." Google supports CRISPR Startup Verve Therapeutics raised $ 58.5 million from sponsors including Google Ventures. What makes Verve different? Most gene therapy companies are focused on rare diseases like hemophilia. But Verve believes that editing people's DNA will help eliminate the most common cause of death. Scientists know that some people have very low cholesterol levels, no matter how hard they try. They even have a Continue Reading

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Оправданы ли риски использования CRISPR? Давайте поразмыслим

Новые заголовки на тему CRISPR появляются каждую неделю, рекламируя потенциал редактирования генов переделать известный нам мир — от создания более подходящих источников пищи до спасения коралловых рифов и улучшения методов лечения рака. Однако бывают и не очень приятные новости: к примеру, есть возможность непреднамеренно повредить ДНК во время редактирования или отредактировать нецелевые участки. Кроме того, учитывая всю сложность механизма ДНК, мы даже и близко не готовы испытывать CRISPR на людях. Официально, во всяком случае — «по-черному» прецеденты уже появляются. Возможности очень большие, и никакое из последствий CRISPR не имеет мгновенного эффекта, хорошего или плохого. Впрочем, область еще в зачаточном состоянии, и при наличии должного объема исследований мы получаем прекрасный потенциал изменить жизнь, сделать ее лучше. Насколько опасен CRISPR? Без исследований — очень И все же, на мой взгляд, мы сталкиваемся с более серьезным препятствием, чем потенциальные недостатки технологии CRISPR. Несмотря на потенциал этого инструмента решить ряд крупнейших мировых проблем, на Continue Reading

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CRISPR injection into the brain of the embryo can cure genetic disorder

A rather controversial new study suggests that there may be a way to prevent Angelman syndrome, a genetic disorder that can cause seizures, difficulties in communication, and is associated with autistic spectrum diseases. The fact is that in order to test the experimental treatment in mice, scientists had to inject CRISPR enzymes, which edit the gene, directly into the brain of the developing fetus. Genetically modified fruits are uncharted ethical territory. Potentially beneficial experimental treatment should be balanced by anxiety about the patient's well-being. As always, on mice The treatment, which was presented at a scientific conference in February, but has not yet been included in academic journals, affects a specific UBE3A gene that helps cells break down and process proteins. When this gene mutates in the developing brain, Angelman syndrome occurs. But research shows that it can be avoided if the genes turn on before birth. In an experiment Continue Reading

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CRISPR technology was first used in the USA for treating cancer patients.

Back in 2016, the US National Institutes of Health allowed a research group from the University of Pennsylvania (UPenn) to begin testing CRISPR (genome editing) technology in humans. Nevertheless, the controversial and earned highly controversial assessment of scientists technology has just now reached the clinical trials in the United States. Representatives of the University of UPenn in an interview with NPR confirmed that they officially began to use it. Scientists point out that this event may lead to a wider use of technology in the future. The CRISPR technology scientists UPenn used to treat two cancer patients in the late stage of the disease. One of them has multiple foci of melanoma, the other suffers from sarcoma. It is noted that patients who were not helped by all the available treatments, agreed to voluntarily go through the CRISPR gene editing program. First, researchers removed the immune system cells from patients Continue Reading

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Genetic engineers made 13,000 changes to a single cell using CRISPR

Since its inception, CRISPR has allowed scientists to make changes in DNA at specific locations in the genome. Often these point changes are made in turn. In any case, it was so before – but a group of scientists from Harvard University said that using this technique made 13,200 genetic changes in one cell. This is a record for gene editing technology. How many changes can I make with CRISPR? A group of scientists led by gene technologist George Church wants to rewrite the genomes on a much larger scale than has been possible to date – which, she said, could ultimately lead to a “radical change” of the species, even a human one. That is, scientists say in plain text that gene editing technologies will change the human species. For better or for worse? Do we recognize ourselves? Editing genes on such a scale has already been tried before. Continue Reading

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Vaccination, chemotherapy, antibiotics … Should CRISPR be prohibited?

Yesterday it became known that several famous people in the field of gene editing want to introduce a global moratorium on editing genes in cells that transmit change to the next generation. Back in 2015, after the first International Human Gene Gene Summit, the organizers unanimously agreed that the creation of genetically modified children would be “irresponsible” if we just didn’t know for sure that it was safe. CRISPR: prohibit cannot be allowed Last year, Chinese scientist He Jiankui edited embryos to create two genetically modified babies. Other groups are also actively seeking opportunities to use this technology to improve people's lives. This prompted people with names in the field of gene editing (some of which subscribed to the statement of 2015) to call for a global moratorium on editing all human germ lines – editing sperm cells or egg cells with hereditary changes. In an open letter to Nature Continue Reading